RNA Details
Disease Name
diabetic nephropathy
Tissue
kidney
RNA Symbol
mir-34a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
dual-luciferase reporter assay
Target
KLOTHO
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
MicroRNA-34a Promotes Renal Fibrosis by Downregulation of Klotho in Tubular Epithelial Cells
Year
2019
Function
"The aberrant upregulation of miR-34a and klotho reduction in obstructed kidney, and markedly ameliorated renal fibrosis in the adriamycin nephropathy and unilateral ureteral obstruction (UUO) model mice."